Everolimus associated interstitial pneumonitis: 3 Case reports

Abstract 

Like sirolimus, everolimus is an inhibitor of mTOR (mammalian target of rapamycin), used as an immunosuppressant in solid organ transplantation and as an antineoplastic agent. Its usage increases. Many cases of sirolimus-induced hypersensitivity pneumonitis were reported. To our knowledge only four cases of everolimus-associated interstitial pneumonitis have been reported in transplant recipients, three in heart and the other in kidney transplantation, with a favourable outcome after discontinuation. We report herein three cases of hypersensitivity pneumonitis due to everolimus.

Keywords: Everolimus, mTOR inhibitor, Hypersensitivity pneumonitis, Sirolimus, Transplantation